Tocotrienols: Vitamin E beyond tocopherols

Tocopherols and tocotrienols as vitamin E

Introduction Vitamins are chemical compounds which are components of coenzymes and non-protein ingredients of enzymes. They are essential for life and normal functioning of the body. Vitamins are supplied with food as they cannot be synthesised by the body [1]. Bad diet, impaired vitamin absorption or the use of substances such as caffeine, nicotine and medicines may lead to hypovitaminosis, th...

Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures

Despite the potential devastating health consequences of intense total-body irradiation, and the decades of research, there still remains a dearth of safe and effective radiation countermeasures for emergency, radiological/nuclear contingencies that have been fully approved and sanctioned for use by the US FDA. Vitamin E is a well-known antioxidant, effective in scavenging free radicals generat...

Vitamin E: Tocotrienols The Science Behind Tocotrienols

Towards the interaction mechanism of tocopherols and tocotrienols (vitamin E) with selected metabolizing enzymes

Vitamin E is a mixture of eight compounds alpha, beta, gamma, delta- tocopherols and alpha, beta, gamma, delta- tocotrienols. Their individual role in cellular transport as antioxidants and in metabolic pathways has been highlighted in the present work. All the eight compounds have been docked with the respective metabolizing enzymes (alpha-tocopherol transfer protein (ATTP), alpha-tocopherol a...

Capillary electrochromatographic evaluation of vitamin E-active oil constituents: tocopherols and tocotrienols.

Separations of lipid antioxidants, tocopherols (T) and tocotrienols (T3), on octylsilica (OS), octadecylsilica (ODS), phenylsilica, or silica were studied by capillary electrochromatography (CEC)-UV detection. The homologues and isomers of the vitamin E-active compounds were best separated with an OS column. CEC with an ODS column tended to yield broad peaks with poor resolution. Among the vari...